Ruboxistaurin Improved Kidney Damage, Function
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Dual protein kinase C alpha and beta inhibitors and diabetic kidney disease: a revisited therapeutic target for future clinical trials
Diabetic kidney disease is the primary cause of chronic kidney disease worldwide, which can progress to end-stage renal disease that requires chronic dialysis therapy or renal transplantation. An improved therapeutic strategy to combat diabetic kidney disease might include blocking the mechanisms by which diabetes leads to renal injury; for example, activation of protein kinase C (PKC). The PKC...
متن کاملThe effect of ruboxistaurin on nephropathy in type 2 diabetes.
OBJECTIVE Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes. The purpose of this study was to evaluate the effects of ruboxistaurin on diabetic nephropathy in humans. RESEARCH DESIGN AND METHODS A randomized, double-blind, placebo-controlled, multicenter, pilot study was performed to evaluate the effects of 32 mg/day ruboxista...
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Harmine is a harmal-derived alkaloid with antioxidant properties. The morphine produces free radicals and plays a key role in the pathogenesis of kidney disease. This study was designed to evaluate the effects of harmine against morphine- induced damage to the kidneys of rats. In this study, 64 male rats were randomly assigned to 8 groups: saline and morphine treated groups; harmine groups (5, ...
متن کاملKidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease.
BACKGROUND A pilot study showed that ruboxistaurin (RBX), a protein kinase C beta inhibitor, significantly decreased albuminuria and stabilized kidney function over 1 yr in patients who had diabetic nephropathy and persistent macroalbuminuria despite receiving the current standard of care, including renin-angiotensin system inhibition. In contrast, in a trial of patients with diabetic retinopat...
متن کاملEffect of Protein Kinase Cβ Inhibition on Renal Hemodynamic Function and Urinary Biomarkers in Humans With Type 1 Diabetes: A Pilot Study
OBJECTIVE The aim of this study was to examine the effect of protein kinase Cbeta inhibition with ruboxistaurin on renal hemodynamic function and urinary biomarkers (monocyte chemoattractant protein-1 [MCP-1] and epidermal growth factor) in renin angiotensin system blockade-treated type 1 diabetic subjects. RESEARCH DESIGN AND METHODS Albuminuric subjects were randomized (2:1) to ruboxistauri...
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